THE SCIENCE BEHIND THE DRG
The DRG is a key epidural, intraspinal nerve structure that houses primary sensory neurons (PSNs) cell bodies. These PSNs embody the primary source of sensory information flow from the periphery to the central nervous system and also represent an important processing point of sensory information. Pain is one type of sensory information that flows and is processed by PSNs within the DRG. Normally, pain represents an important protective sensory experience, but in pathological conditions, pain becomes a chronic condition. Research has shown PSNs in the DRG are critically involved in the development and maintenance of chronic pain. Similarly, these neurons exhibit altered membrane properties such as increased excitability as well as abnormal and ectopic activity.